Centanafadine – (924012-43-1)

Centanafadine, also known as EB-1020, is a novel serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) under development for the treatment of attention-deficit hyperactivity disorder (ADHD). With a unique pharmacological profile, it inhibits the reuptake of norepinephrine, dopamine, and serotonin. Originally developed by Euthymics Bioscience, the rights to centanafadine were acquired by Neurovance in 2011, and subsequently by Otsuka Pharmaceutical in 2017. As of 2025, it is in Phase II and III clinical trials, indicating its potential as a new therapeutic option for ADHD.

Centanafadine’s mechanism of action involves blocking the reuptake of norepinephrine, dopamine, and serotonin, which are key neurotransmitters involved in attention, focus, and mood regulation. Preclinical studies have shown that it preferentially inhibits norepinephrine and dopamine transporters, while exhibiting a lesser effect on the serotonin transporter. This selective inhibition profile suggests a favorable balance between efficacy and potential side effects.

In clinical trials, centanafadine has demonstrated significant efficacy in reducing ADHD symptoms. Phase III studies involving adults aged 18-55 with moderate to severe ADHD showed statistically significant improvements in the Adult ADHD Investigator Symptom Rating Scale (AISRS) total score compared to placebo. The treatment was well-tolerated, with a low incidence of serious adverse events and a minimal risk of abuse potential. These findings support centanafadine’s potential as a safe and effective treatment for ADHD, offering a new alternative to existing stimulant and non-stimulant medications.

The above information is displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.

Sources:

https://en.wikipedia.org/wiki/Centanafadine
https://pubchem.ncbi.nlm.nih.gov/compound/16095349
https://www.medchemexpress.com/Centanafadine.html
https://www.medkoo.com/products/41832
https://pubmed.ncbi.nlm.nih.gov/35652746/