Galantamine is a tertiary alkaloid and reversible, competitive inhibitor of acetylcholinesterase (AChE), primarily used to treat mild to moderate Alzheimer’s disease. It is extracted from plants like Galanthus nivalis (snowdrop) or synthesized.
Galantamine increases acetylcholine levels by inhibiting AChE, enhancing cholinergic neurotransmission, and modulating nicotinic receptors.
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| Other Names | 5-Methoxy-9-methyl-2, 3, 3a, 3a1, 8, 9, 10, 11-octahydro-4-oxa-9-azacycloocta[def]fluoren-2-ol hydrobromide, Benzofuro[4, 3, 2-efg][2]benzazocin-2-ol, 2, 3, 3a, 8, 9, 10, 11, 11b-octahydro-5-methoxy-9-methyl-, hydrobromide (9CI), DKGIHQCMWKXHHR-UHFFFAOYSA-N, DTXSID701015685 |
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| IUPAC Name | 2-methoxy-7-methyl-17-oxa-7-azatetracyclo[12.2.1.05, 16.010, 15]heptadeca-1, 3, 5(16), 10-tetraen-12-ol;hydrobromide |
| CAS | 69353-21-5 |
| Molecular Weight | 368.3 |
| Molecular Formula | C17H22BrNO3 |
| SMILES | CN1CCC2=CC(CC3C2C4=C(C1)C=CC(=C4O3)OC)O.Br |