Guvacine – (498-96-4)

Guvacine is a tetrahydropyridine alkaloid found in areca nuts, known for its potent inhibitory effects on gamma-aminobutyric acid (GABA) uptake. It is the N-demethylated derivative of arecaidine and the product of ester hydrolysis of guvacoline, both also present in areca nuts. Guvacine selectively binds to presynaptic GABA reuptake transporters, preventing GABA reuptake without interacting with GABA postsynaptic receptors.

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Sources:

https://en.wikipedia.org/wiki/Guvacine
https://pubchem.ncbi.nlm.nih.gov/compound/3532
https://www.medchemexpress.com/guvacine.html
https://www.medkoo.com/products/16095
https://www.sciencedirect.com/topics/medicine-and-dentistry/guvacine
https://www.researchgate.net/publication/362562777_Alternative_Synthesis_of_the_Alkaloid_Guvacine_and_Its_Derivatives