HA-966 HCl – (42585-88-6)

HA-966 is a molecule used in scientific research as a glycine receptor and NMDA receptor antagonist/low-efficacy partial agonist. It exhibits neuroprotective, anticonvulsant, anxiolytic, antinociceptive, and sedative/hypnotic effects in animal models.

HA-966 has two enantiomers with distinct pharmacological activities: the (R)-(+)-enantiomer acts as a glycine/NMDA receptor antagonist, while the (S)-(-)-enantiomer induces sedative and ataxic effects. HA-966, a derivative, is a glycine site antagonist of the NMDA receptor, blocking glycine-enhanced NMDA responses competitively. Studies show HA-966 impairs visual recognition memory in rhesus monkeys, suggesting its action on the glycine modulatory site of the NMDA receptor complex.

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Sources:

https://en.wikipedia.org/wiki/HA-966
https://www.medchemexpress.com/ha-966-hydrochloride.html
https://www.medkoo.com/products/44731
https://www.sciencedirect.com/science/article/abs/pii/0006899396004635
https://pubmed.ncbi.nlm.nih.gov/8883856/