JJC8-088 – (1627576-82-2)

JJC8-088 is a potent dopamine transporter (DAT) inhibitor derived from the wakefulness-promoting agent modafinil. With a substantially higher affinity for the dopamine transporter compared to modafinil, JJC8-088 exhibits cocaine-like psychostimulant effects and robustly increases dopamine levels in the nucleus accumbens.

Unlike modafinil, which is an atypical dopamine reuptake inhibitor, JJC8-088 acts as a typical cocaine-like dopamine reuptake inhibitor, stabilizing the DAT in an outward-facing open conformation.

JJC8-088 has been shown to effectively reduce compulsive self-administration of methamphetamine in rats and increase extracellular dopamine levels in rats with a history of cocaine self-administration.

The above information is displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.

Sources:

https://en.wikipedia.org/wiki/JJC8-088
https://pubchem.ncbi.nlm.nih.gov/compound/118643968
https://www.medchemexpress.com/jjc8-088.html
https://www.medkoo.com/products/53271
https://www.sciencedirect.com/science/article/pii/S0022356524004105
https://jpet.aspetjournals.org/article/S0022-3565(24)00091-0/fulltext