6-Paradol – (27113-22-0)

Paradol, also known as 6-Paradol, is a pungent phenolic compound found in ginger and other Zingiberaceae plants. It is the active flavor constituent of the seeds of Guinea pepper (Aframomum melegueta or grains of paradise).

Paradol has been identified to possess antioxidant and antitumor-promoting effects, particularly in mouse models. It binds to the cyclooxygenase (COX)-2 active site, making it an effective inhibitor of tumor promotion in skin carcinogenesis.

Paradol is also used in flavorings as an essential oil to impart spiciness. Paradol has shown potential in inducing apoptosis in cancer cells and reducing neuroinflammatory responses in activated microglia.

The above informationis displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.

Sources:

https://en.wikipedia.org/wiki/Paradol
https://pubchem.ncbi.nlm.nih.gov/compound/94378
https://www.medchemexpress.com/Paradol.html
https://www.medkoo.com/products/10356
https://www.sciencedirect.com/science/article/abs/pii/S175646461730083X
https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.202100185