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Adipotide – (859216-15-2)
Adipotide - (859216-15-2)

Adipotide – (859216-15-2)

Adipotide is a peptidomimetic compound. It functions as a pro-apoptotic drug, targeting specific blood vessels that supply white adipose tissue. By binding to receptors prohibitin and ANXA2, Adipotide induces vascular apoptosis, leading to the shrinkage of blood vessels and subsequent apoptosis of fat cells.

This mechanism results in rapid weight loss, as demonstrated in studies involving mice and rhesus monkeys.

However, clinical development of Adipotide was discontinued as of 2019. Its unique action on white adipose tissue makes it a potential candidate for anti-obesity therapies, though further research is needed to assess its safety and efficacy in humans.

The above information is displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.

SKU: 859216-15-2
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Adipotide is a peptidomimetic compound. It functions as a pro-apoptotic drug, targeting specific blood vessels that supply white adipose tissue. By binding to receptors prohibitin and ANXA2, Adipotide induces vascular apoptosis, leading to the shrinkage of blood vessels and subsequent apoptosis of fat cells.

This mechanism results in rapid weight loss, as demonstrated in studies involving mice and rhesus monkeys.

However, clinical development of Adipotide was discontinued as of 2019. Its unique action on white adipose tissue makes it a potential candidate for anti-obesity therapies, though further research is needed to assess its safety and efficacy in humans.

The above informationis displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.
Sources:
https://en.wikipedia.org/wiki/Prohibitin-targeting_peptide_1
https://pubchem.ncbi.nlm.nih.gov/compound/163360068
https://pmc.ncbi.nlm.nih.gov/articles/PMC3666164/
https://www.peptidesciences.com/blog/adipotide
https://arrowheadpharma.com/news-press/arrowhead-announces-fda-clearance-to-initiate-adipotide-phase-i-clinical-trial/
Other Names

Adipotide, HKPao, EX-A6186, DA-74204

IUPAC Name

(2R)-6-amino-2-[[(2R)-2-[[(2R)-2-[[(2R)-6-amino-2-[[(2R)-2-[[(2R)-2-[[(2R)-6-amino-2-[[(2R)-6-amino-2-[[(2R)-2-[[(2R)-2-[[(2R)-6-amino-2-[[(2R)-2-[[(2R)-2-[[(2R)-6-amino-2-[[2-[[2-[[(2R)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-6-amino-2-[[(2R)-2-amino-3-sulfanylpropanoyl]amino]hexanoyl]amino]acetyl]amino]acetyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]amino]hexanoyl]amino]-3-carboxypropanoyl]amino]-3-sulfanylpropanoyl]amino]acetyl]amino]acetyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]hexanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]hexanoic acid

CAS

859216-15-2

Molecular Weight

2557.2

Molecular Formula

C111H206N36O28S2

SMILES

C[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CS)C(=O)NCC(=O)NCC(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](C)C(=O)N[C@H](CCCCN)C(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CS)N

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