Basmisanil – (1159600-41-5)

Basmisanil (RG1662) is a highly selective inverse agonist/negative allosteric modulator of α5 subunit-containing GABAA receptors.

It was under development by Roche for the treatment of cognitive impairment associated with Down syndrome.

As of June 2016, it is no longer studied for this purpose. It has also undergone clinical trials for cognitive impairment in patients with schizophrenia.

The above information is displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.

Basmisanil (RG1662) is a highly selective inverse agonist/negative allosteric modulator of α5 subunit-containing GABAA receptors.

It was under development by Roche for the treatment of cognitive impairment associated with Down syndrome.

As of June 2016, it is no longer studied for this purpose. It has also undergone clinical trials for cognitive impairment in patients with schizophrenia.

The above informationis displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.

Sources:

https://en.wikipedia.org/wiki/Basmisanil
https://pubchem.ncbi.nlm.nih.gov/compound/57336276
https://www.medchemexpress.com/Basmisanil.html
https://www.medkoo.com/products/7804
https://www.nature.com/articles/s41598-021-87307-7
https://www.sciencedirect.com/science/article/abs/pii/S0304394024002064

Other Names	Basmisanil, Basmisanil [INN], (1, 1-Dioxidothiomorpholino)(6-((3-(4-fluorophenyl)-5-methylisoxazol-4-yl)methoxy)pyridin-3-yl)methanone, Basmisanil (RG1662)
IUPAC Name	(1, 1-dioxo-1, 4-thiazinan-4-yl)-[6-[[3-(4-fluorophenyl)-5-methyl-1, 2-oxazol-4-yl]methoxy]pyridin-3-yl]methanone
CAS	1159600-41-5
Molecular Weight	445.5
Molecular Formula	C21H20FN3O5S
SMILES	CC1=C(C(=NO1)C2=CC=C(C=C2)F)COC3=NC=C(C=C3)C(=O)N4CCS(=O)(=O)CC4

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Basmisanil – (1159600-41-5)

Basmisanil (RG1662) is a highly selective inverse agonist/negative allosteric modulator of α5 subunit-containing GABAA receptors.

It was under development by Roche for the treatment of cognitive impairment associated with Down syndrome.

As of June 2016, it is no longer studied for this purpose. It has also undergone clinical trials for cognitive impairment in patients with schizophrenia.

The above informationis displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.

Sources:

https://en.wikipedia.org/wiki/Basmisanil
https://pubchem.ncbi.nlm.nih.gov/compound/57336276
https://www.medchemexpress.com/Basmisanil.html
https://www.medkoo.com/products/7804
https://www.nature.com/articles/s41598-021-87307-7
https://www.sciencedirect.com/science/article/abs/pii/S0304394024002064

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Basmisanil – (1159600-41-5)

Basmisanil (RG1662) is a highly selective inverse agonist/negative allosteric modulator of α5 subunit-containing GABAA receptors.

It was under development by Roche for the treatment of cognitive impairment associated with Down syndrome.

As of June 2016, it is no longer studied for this purpose. It has also undergone clinical trials for cognitive impairment in patients with schizophrenia.

The above informationis displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.

Sources:

https://en.wikipedia.org/wiki/Basmisanil https://pubchem.ncbi.nlm.nih.gov/compound/57336276 https://www.medchemexpress.com/Basmisanil.html https://www.medkoo.com/products/7804 https://www.nature.com/articles/s41598-021-87307-7 https://www.sciencedirect.com/science/article/abs/pii/S0304394024002064

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https://en.wikipedia.org/wiki/Basmisanil
https://pubchem.ncbi.nlm.nih.gov/compound/57336276
https://www.medchemexpress.com/Basmisanil.html
https://www.medkoo.com/products/7804
https://www.nature.com/articles/s41598-021-87307-7
https://www.sciencedirect.com/science/article/abs/pii/S0304394024002064