CJC-1295 is a synthetic analogue of growth hormone-releasing hormone (GHRH) and a growth hormone secretagogue (GHS) developed by ConjuChem Biotechnologies.
It is a modified form of GHRH (1-29) with improved pharmacokinetics, particularly in terms of half-life. CJC-1295 may significantly increase plasma growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels in both animals and humans.
A single injection could elevate plasma GH levels by 2- to 10-fold for up to 6 days and IGF-1 levels by 0.5- to 3-fold for 9 to 11 days. The drug has an estimated half-life of 6 to 8 days in humans due to the addition of a drug affinity complex (DAC) that binds to albumin, prolonging its presence in the bloodstream.
CJC-1295 is primarily used for its potential to stimulate GH release from the pituitary gland. It was investigated for treating lipodystrophy and growth hormone deficiency but was discontinued after a trial subject’s death.
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| CAS | 446262-90-4 |
|---|---|
| Molecular Weight | 3367.9 |
| Molecular Formula | C152H252N44O42 |
| SMILES | CCC(C)C(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)O)C(=O)NC(CCC(=O)N)C(=O)NC(CO)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(CCC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)N)C(=O)NC(CC(=O)O)C(=O)NC(C(C)CC)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCCNC(=N)N)C(=O)N)NC(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(C)NC(=O)C(CC3=CC=C(C=C3)O)N |