(-)clausenamide – (201529-58-0)

(-)-Clausenamide is an active alkaloid isolated from the leaves of Clausena lansium. It improves cognitive function in both normal physiological and pathological conditions by inhibiting β-amyloid (Aβ) toxicity and blocking neurofibrillary tangle formation through the inhibition of tau protein phosphorylation. It exhibits significant neuroprotective activity against Aβ 25-35 and is used for researching Alzheimer’s disease (AD).

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Sources:

https://www.medchemexpress.com/minus-clausenamide.html

https://www.medkoo.com/products/12503

https://pubmed.ncbi.nlm.nih.gov/22366429/

https://www.tandfonline.com/doi/abs/10.1179/016164103101202219