Compound 7P is a synthetic small molecule, identified as a thromboxane receptor antagonist and synthase inhibitor. Compound 7P has shown potential in promoting neurite outgrowth in cultured primary neurons derived from the hippocampus, cerebral cortex, and retina. In animal models of optic nerve injury, it has been demonstrated to induce the growth of GAP-43-positive axons, indicating its ability to stimulate axon regeneration in vivo.
This compound also exhibits selectivity for prostaglandin I2 synthase (PTGIS, CYP8A1) over thromboxane synthase (CYP5A1). Additionally, Compound 7P has been studied for its neuroprotective properties, potential to enhance memory, improve concentration, and modulate mood by influencing neurotransmitters like serotonin and dopamine.
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| Other Names | 2-((N-(2-Methoxyphenyl)-4-methylphenyl)sulfonamido)-N-(4-methoxypyridin-3-yl)acetamide, 2-[(2-methoxyphenyl)[(4-methylphenyl)sulfonyl]amino]-N-(4-methoxy-3-pyridinyl)acetamide, CHEMBL3824120 |
|---|---|
| IUPAC Name | 2-(2-methoxy-N-(4-methylphenyl)sulfonylanilino)-N-(4-methoxypyridin-3-yl)acetamide |
| CAS | 1890208-58-8 |
| Molecular Weight | 441.5 |
| Molecular Formula | C22H23N3O5S |
| SMILES | CC1=CC=C(C=C1)S(=O)(=O)N(CC(=O)NC2=C(C=CN=C2)OC)C3=CC=CC=C3OC |