Enclomiphene – (15690-57-0)

Enclomiphene, also known as (E)-Clomiphene or trans-Clomiphene, is a non-steroidal selective estrogen receptor modulator (SERM) that acts as an estrogen receptor antagonist. It is one of the two stereoisomers of clomiphene, with the other being zuclomiphene.

Enclomiphene primarily antagonizes estrogen receptors in the pituitary gland, reducing negative feedback by estrogen on the hypothalamic-pituitary-gonadal axis. This action increases gonadotropin secretion, leading to enhanced testosterone production in men.

Enclomiphene has been investigated for the treatment of male hypogonadism and type 2 diabetes. Unlike testosterone replacement therapy, enclomiphene stimulates endogenous testosterone production without suppressing spermatogenesis.

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Sources:

https://en.wikipedia.org/wiki/Enclomifene
https://www.medchemexpress.com/enclomiphene.html
https://www.medkoo.com/products/45808
https://conciergemdla.com/blog/enclomiphene-therapy-science/