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Humanin – (330936-69-1)
Humanin - (330936-69-1)

Humanin – (330936-69-1)

Humanin is a micropeptide encoded in the mitochondrial genome by the 16S ribosomal RNA gene, MT-RNR2. It is a 21 or 24-amino-acid peptide, depending on whether it is produced inside or outside the mitochondria.

Humanin has cytoprotective effects, protecting cells from oxidative stress, serum starvation, hypoxia, and other insults. It is involved in neuroprotection, particularly against Alzheimer’s disease-related neurotoxicity, and has been shown to improve insulin sensitivity and glucose tolerance.

Humanin interacts with various proteins, including BAX, IGFBP3, and TRIM11, and has been found to have anti-apoptotic properties. It is also implicated in cardiovascular protection and has been studied for its potential therapeutic applications in neurodegenerative diseases, stroke, and diabetes. Humanin levels decline with age, suggesting a role in aging and age-related diseases.

The above information is displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.

SKU: 330936-69-1
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Humanin is a micropeptide encoded in the mitochondrial genome by the 16S ribosomal RNA gene, MT-RNR2. It is a 21 or 24-amino-acid peptide, depending on whether it is produced inside or outside the mitochondria.

Humanin has cytoprotective effects, protecting cells from oxidative stress, serum starvation, hypoxia, and other insults. It is involved in neuroprotection, particularly against Alzheimer’s disease-related neurotoxicity, and has been shown to improve insulin sensitivity and glucose tolerance.

Humanin interacts with various proteins, including BAX, IGFBP3, and TRIM11, and has been found to have anti-apoptotic properties. It is also implicated in cardiovascular protection and has been studied for its potential therapeutic applications in neurodegenerative diseases, stroke, and diabetes. Humanin levels decline with age, suggesting a role in aging and age-related diseases.

The above informationis displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.
Sources:
https://en.wikipedia.org/wiki/Humanin
https://www.medchemexpress.com/humanin.html
https://www.sciencedirect.com/topics/medicine-and-dentistry/humanin
https://jme.bioscientifica.com/view/journals/jme/50/1/R11.xml
Other Names

formyl humanin, Protein Humanin (human), HUMANIN TRIFLUOROACETATE

IUPAC Name

(4S)-5-[[(2S, 3S)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-5-carbamimidamido-1-[[(2S)-5-carbamimidamido-1-[[(1S)-1-carboxyethyl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-4-methyl-1-oxopentan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-[[(2S)-2-[[(2S, 3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoic acid

CAS

330936-69-1

Molecular Weight

2687.2

Molecular Formula

C119H204N34O32S2

SMILES

CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CO)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](C)NC(=O)[C@H](CCSC)N

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