Huperzine A – (102518-79-6)

Huperzine A is a naturally occurring sesquiterpene alkaloid found in the firmoss Huperzia serrata and other related species. It is a potent, reversible, and selective inhibitor of acetylcholinesterase (AChE), an enzyme that breaks down the neurotransmitter acetylcholine (ACh).

By inhibiting AChE, Huperzine A increases acetylcholine levels in the brain, which may improve cognitive function. It also acts as a non-competitive antagonist of the NMDA receptor, providing neuroprotective effects.

Huperzine A has been investigated for its potential in treating neurodegenerative diseases, particularly Alzheimer’s disease, though evidence from clinical studies remains inconclusive due to methodological limitations.

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Sources:

https://en.wikipedia.org/wiki/Huperzine_A
https://www.medchemexpress.com/_-_-Huperzine-A.html
https://www.medkoo.com/products/4959
https://www.sciencedirect.com/topics/medicine-and-dentistry/huperzine-a