Lemairamin – (29946-61-0)

Lemairamin, also known as Wgx-50, is a compound derived from the Zanthoxylum plant that has demonstrated significant potential in alleviating pain hypersensitivity and intestinal inflammation. In a study published in the journal Biochemical and Biophysical Research Communications, researchers found that lemairamin acts as an agonist of α7 nicotinic acetylcholine receptors (α7nAChRs), effectively reducing neuroinflammation associated with conditions like Alzheimer’s disease.

In another study published in the International Journal of Molecular Sciences, researchers explored the therapeutic potential of lemairamin in inflammatory bowel disease (IBD) using a zebrafish model of dextran sulfate sodium (DSS)-induced colitis. The results demonstrated that lemairamin reduced the expression of pro-inflammatory cytokines and inhibited neutrophil recruitment to the site of intestinal injury. The anti-inflammatory effects of lemairamin were attributed to its regulation of the Akt pathway, suggesting its potential as a novel treatment for IBD.

The above informationis displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.

Sources:

https://pubmed.ncbi.nlm.nih.gov/32184015/
https://pubmed.ncbi.nlm.nih.gov/39273457/