Phenibut – (1078-21-3)

Phenibut, also known as β-phenyl-γ-aminobutyric acid, is a neuropsychotropic drug that acts as a GABA-mimetic, primarily targeting GABA(B) receptors and, to a lesser extent, GABA(A) receptors. Initially developed in the Soviet Union in the 1960s, phenibut has been used clinically to alleviate anxiety, tension, and fear, improve sleep, and as a pre- or post-operative medication. It is also prescribed for conditions characterized by asthenia, depression, post-traumatic stress, stuttering, and vestibular disorders.

Phenibut’s structure is similar to that of baclofen, with the key difference being the absence of a chlorine atom in the para-position of the phenyl group. This structural similarity extends to its pharmacological profile, as phenibut exhibits anxiolytic and nootropic (cognitive-enhancing) properties. It stimulates dopamine receptors and antagonizes β-phenethylamine, a putative endogenous anxiogenic.

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Sources:

https://en.wikipedia.org/wiki/Phenibut
https://www.medchemexpress.com/phenibut.html
https://www.medkoo.com/products/20023
https://pubmed.ncbi.nlm.nih.gov/11830761/
https://psychonautwiki.org/wiki/Phenibut