PQQ – (122628-50-6)

Pyrroloquinoline quinone (PQQ), also known as methoxatin, is a redox cofactor and antioxidant that plays a crucial role in bacterial growth and metabolism. Initially discovered in 1964 by J.G. Hauge, PQQ was identified as the third redox cofactor in bacteria after nicotinamide and flavin. It was later extracted from methanol dehydrogenase of methylotrophs and its molecular structure was determined. PQQ is biosynthesized in bacteria from a ribosomally translated precursor peptide, PqqA, through a series of enzymatic reactions involving radical SAM enzymes.

In mammals, PQQ is considered an essential nutrient and is important for immune function. It has been shown to stimulate growth in bacteria and is involved in the redox metabolism and structural integrity of cells and tissues. PQQ is found in various eukaryotic proteins, where it acts as a cofactor, enhancing reactions by catalyzing the oxidation of NADH via redox cycling.

Despite its importance, the role of PQQ as a vitamin has been controversial. While some studies suggest it is a “longevity vitamin” necessary for long-term health, others argue that it is not essential for immediate survival. PQQ’s unique properties and potential health benefits have made it a subject of extensive research, particularly in the fields of nutrition and biochemistry.

PQQ is available in various forms, including its disodium salt and derivatives, and is used in scientific research for its potential applications in health and disease management. Its chemical structure, solubility, and biological activity make it a versatile compound for in vitro and in vivo studies. Researchers continue to explore its mechanisms of action and potential therapeutic applications, making PQQ a compound of significant interest in the scientific community.

The above information is displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.

Sources:

https://en.wikipedia.org/wiki/Pyrroloquinoline_quinone
https://www.medchemexpress.com/pyrroloquinoline-quinone.html