PRL-8-53 – (51352-88-6)

PRL-8-53 is a nootropic compound derived from benzoic acid and phenylmethylamine, initially synthesized by Dr. Nikolaus Hansl at Creighton University in the 1970s. Known for its potential to enhance cognitive function, PRL-8-53 has been shown to improve learning and retention of verbal information in human subjects.

The compound does not exhibit stimulant properties and does not potentiate the effects of dextroamphetamine in rats. PRL-8-53 is relatively non-toxic, with an oral LD50 in mice of 860 mg/kg, indicating a high therapeutic index.

Despite its promising cognitive benefits, further development of PRL-8-53 was discontinued, partly due to the retirement of its creator and a legal dispute with Creighton University.

The above information is displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.

Sources:

https://en.wikipedia.org/wiki/PRL-8-53
https://www.medchemexpress.com/prl-8-53.html
https://www.medkoo.com/products/51319
https://pubmed.ncbi.nlm.nih.gov/418433/