S-17092 – (176797-26-5)

S-17092 is a potent and selective inhibitor of the enzyme prolyl endopeptidase (PEP), which plays a crucial role in the metabolic breakdown of neuropeptide neurotransmitters in the brain. By inhibiting PEP, S-17092 increases the activity of these neuropeptides, leading to nootropic effects that make it a promising treatment for neurodegenerative conditions such as Alzheimer’s and Parkinson’s diseases.

Preclinical studies have demonstrated S-17092’s efficacy in enhancing memory and cognitive function in aged mice, rodents, and monkeys with induced amnesia or spontaneous memory deficits. Clinical trials have shown that S-17092 is safe for human use and exhibits a clear peripheral expression of its mechanism of action through the inhibition of PEP activity in plasma. Additionally, EEG recordings in healthy volunteers have indicated central effects, with improvements observed in delayed verbal memory tasks. S-17092’s potential as a therapeutic agent for cognitive disorders associated with cerebral aging is supported by both preclinical and clinical findings.

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Sources:

https://en.wikipedia.org/wiki/S-17092
https://pubchem.ncbi.nlm.nih.gov/compound/9929984
https://www.medchemexpress.com/s-17092.html
https://www.medkoo.com/products/7304
https://www.sciencedirect.com/science/article/abs/pii/S0006291X99903662
https://pubmed.ncbi.nlm.nih.gov/12070525/