S-18986 – (175340-20-2)

S-18986 is a positive allosteric modulator of AMPA-type glutamate receptors, known for its cognitive-enhancing properties. This compound has demonstrated significant potential in improving memory and cognitive functions, particularly in the context of aging and neurodegenerative diseases. S-18986 increases the induction and maintenance of long-term potentiation (LTP) in the hippocampus, a key mechanism underlying learning and memory. Additionally, it enhances the expression of brain-derived neurotrophic factor (BDNF), which plays a crucial role in neuronal survival and growth.

In animal studies, S-18986 has shown robust memory-enhancing effects, particularly in middle-aged rodents compared to aged ones. It exhibits antiamnesic properties in spatial memory tasks and improves performance in various behavioral models, including procedural, spatial, episodic, working, and relational/declarative memory. The compound’s ability to activate the release of noradrenaline and acetylcholine in the rat hippocampus further underscores its potential as a therapeutic agent for cognitive disorders.

S-18986’s pharmacological profile suggests it could be a valuable tool in the treatment of cognitive deficits associated with early cerebral aging and neurological diseases such as Alzheimer’s. Its selectivity and brain penetrance make it a promising candidate for clinical development. However, further research is needed to fully understand its mechanisms of action and to validate its efficacy in human subjects.

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Sources:

https://en.wikipedia.org/wiki/S-18986
https://pubchem.ncbi.nlm.nih.gov/compound/637863
https://www.medchemexpress.com/s-18986.html
https://www.medkoo.com/products/11268
https://pubmed.ncbi.nlm.nih.gov/21050420/
https://www.sciencedirect.com/science/article/abs/pii/S0014488607003901