SKF-38393 is a synthetic compound belonging to the benzazepine chemical class, known for its role as a selective D1/D5 receptor partial agonist. This compound exhibits stimulant and anorectic properties, making it a subject of interest in various research fields. Studies have shown that SKF-38393 can enhance temporal order memory performance in maternally deprived rats and reverse cocaine-conditioned place preference in mice. Additionally, it has been found to induce GAP-43 expression and long-term potentiation in the hippocampus in vivo.
In a study published in Neuroscience, researchers investigated the effect of SKF-38393 on the spontaneous release of glutamate from cultured rat hippocampal neurons. The results demonstrated that SKF-38393 increased the frequency, but not the amplitude, of tetrodotoxin-resistant excitatory postsynaptic currents, suggesting a presynaptic site of action. This effect was blocked by the D1-dopaminergic receptor antagonist SCH-23390 and protein kinase A inhibitors, indicating a mechanism dependent on D1-type dopamine receptors and protein kinase A.
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Sources:
https://en.wikipedia.org/wiki/SKF-38,393
https://pubchem.ncbi.nlm.nih.gov/compound/1242
https://www.medkoo.com/products/11794
https://pubmed.ncbi.nlm.nih.gov/10625048/
https://www.ibroneuroscience.org/article/S0306-4522(99)00352-8/abstract
