Toremifene is a selective estrogen receptor modulator (SERM) primarily used in the treatment of metastatic breast cancer in postmenopausal women with estrogen receptor-positive or unknown-status tumors.
Toremifene is a mixed agonist–antagonist of the estrogen receptor, with estrogenic effects in bone, the liver, and the uterus, and antiestrogenic effects in the breasts. It is a triphenylethylene derivative and is closely related to tamoxifen. Introduced in 1997, it was the first new antiestrogen to be introduced since tamoxifen in 1978.
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| Other Names | Fareston, FC 1157a |
|---|---|
| IUPAC Name | 2-[4-[(Z)-4-chloro-1, 2-diphenylbut-1-enyl]phenoxy]-N, N-dimethylethanamine;2-hydroxypropane-1, 2, 3-tricarboxylic acid |
| CAS | 89778-27-8 |
| Molecular Weight | 598.1 |
| Molecular Formula | C32H36ClNO8 |
| SMILES | CN(C)CCOC1=CC=C(C=C1)/C(=C(/CCCl)\C2=CC=CC=C2)/C3=CC=CC=C3.C(C(=O)O)C(CC(=O)O)(C(=O)O)O |