Vialox Peptide, also known as Pentapeptide-3, is a synthetic peptide derived from the venom of the Temple Viper. It is a pentapeptide fragment of the neurotoxin waglerin-1 and is composed of the amino acid sequence GPRPA. Vialox acts as a competitive antagonist of nicotinic acetylcholine receptors (nAChRs), specifically targeting the postsynaptic membrane of muscle cells. By blocking these receptors, Vialox inhibits the transmission of nerve signals to muscles, preventing muscle contraction and inducing a muscle-relaxing effect similar to that of tubocurarine, a natural alkaloid.
Research suggests that Vialox’s mechanism of action may lead to significant anti-aging effects, particularly in reducing the appearance of wrinkles and fine lines on the skin. Studies have shown that Vialox can decrease muscular contractions, leading to a reduction in wrinkle depth and skin roughness. In one study, it was found to reduce muscular contractions by 71% within one minute and by 58% after two hours. Over a 28-day period, continuous application of Vialox resulted in a 49% reduction in wrinkle size and a 47% decrease in skin roughness.
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| Other Names | Pentapeptide-3, Glycyl-L-prolyl-L-arginyl-L-prolyl-L-alaninamide |
|---|---|
| IUPAC Name | (2S)-1-(2-aminoacetyl)-N-[(2S)-1-[(2S)-2-[[(2S)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]pyrrolidine-2-carboxamide |
| CAS | 135679-88-8 |
| Molecular Weight | 495.6 |
| Molecular Formula | C21H37N9O5 |
| SMILES | C[C@@H](C(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]2CCCN2C(=O)CN |