ZJ43 – (723331-20-2)

ZJ43 is a potent inhibitor of NAAG peptidase, an enzyme that hydrolyzes the neurotransmitter N-acetylaspartylglutamate (NAAG) into N-acetylaspartate (NAA) and glutamate. ZJ43 effectively inhibits NAAG peptidase activity, leading to increased NAAG levels in the synaptic space. This mechanism of action is significant because NAAG acts as a neurotransmitter that selectively activates presynaptic Group II metabotropic glutamate receptor subtype 3 (mGluR3), which in turn suppresses glutamate transmission. By prolonging the presence of NAAG, ZJ43 reduces glutamate excitotoxicity, which is implicated in various neurological conditions, including traumatic brain injury (TBI) and pain.

In studies, ZJ43 has demonstrated neuroprotective effects in animal models of TBI. For instance, when administered after moderate lateral fluid percussion TBI in rats, ZJ43 significantly reduced the number of degenerating neurons and decreased astrocyte loss in the hippocampus. These protective effects were abolished when ZJ43 was co-administered with the Group II mGluR antagonist LY341495, underscoring the role of mGluR3 in mediating NAAG’s neuroprotective actions. Additionally, ZJ43 has shown analgesic properties in neuropathic and inflammatory pain models, further highlighting its therapeutic potential.

ZJ43 is a urea-based analog of NAAG and is part of a class of compounds that includes other NAAG peptidase inhibitors like ZJ11 and ZJ17. These inhibitors have been investigated for their potential in treating neurological disorders and managing pain. The compound is soluble in DMSO and can be formulated for research use, with a recommended storage condition of -20°C for long-term preservation.

The above information is displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.

ZJ43 is a potent inhibitor of NAAG peptidase, an enzyme that hydrolyzes the neurotransmitter N-acetylaspartylglutamate (NAAG) into N-acetylaspartate (NAA) and glutamate. ZJ43 effectively inhibits NAAG peptidase activity, leading to increased NAAG levels in the synaptic space. This mechanism of action is significant because NAAG acts as a neurotransmitter that selectively activates presynaptic Group II metabotropic glutamate receptor subtype 3 (mGluR3), which in turn suppresses glutamate transmission. By prolonging the presence of NAAG, ZJ43 reduces glutamate excitotoxicity, which is implicated in various neurological conditions, including traumatic brain injury (TBI) and pain.

In studies, ZJ43 has demonstrated neuroprotective effects in animal models of TBI. For instance, when administered after moderate lateral fluid percussion TBI in rats, ZJ43 significantly reduced the number of degenerating neurons and decreased astrocyte loss in the hippocampus. These protective effects were abolished when ZJ43 was co-administered with the Group II mGluR antagonist LY341495, underscoring the role of mGluR3 in mediating NAAG’s neuroprotective actions. Additionally, ZJ43 has shown analgesic properties in neuropathic and inflammatory pain models, further highlighting its therapeutic potential.

ZJ43 is a urea-based analog of NAAG and is part of a class of compounds that includes other NAAG peptidase inhibitors like ZJ11 and ZJ17. These inhibitors have been investigated for their potential in treating neurological disorders and managing pain. The compound is soluble in DMSO and can be formulated for research use, with a recommended storage condition of -20°C for long-term preservation.

The above information is displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.

Sources:

https://en.wikipedia.org/wiki/N-Acetylaspartylglutamic_acid
https://pubchem.ncbi.nlm.nih.gov/compound/11722553
https://www.medchemexpress.com/zj43.html
https://www.medkoo.com/products/41009
https://pubmed.ncbi.nlm.nih.gov/15716632/
https://gojirafc.com/chemical/zj43potent-inhibitor-of-glutamate-carboxypeptidases-ii-and-iii/

Other Names	ZJ 43, ZJ-43
IUPAC Name	(2S)-2-[[(1S)-1-carboxy-3-methylbutyl]carbamoylamino]pentanedioic acid
CAS	723331-20-2
Molecular Weight	304.3
Molecular Formula	C12H20N2O7
SMILES	CC(C)C[C@@H](C(=O)O)NC(=O)N[C@@H](CCC(=O)O)C(=O)O