Clomiphene citrate, also known as clomifene citrate, is a molecule primarily used to treat infertility in women who do not ovulate, including those with polycystic ovary syndrome (PCOS). It is taken orally and belongs to the selective estrogen receptor modulator (SERM) family of medications.
Clomiphene citrate works by blocking estrogen receptors in the hypothalamus, leading to an increase in the release of gonadotropin-releasing hormone (GnRH), which in turn stimulates the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. This hormonal cascade promotes ovulation.
It has also been studied for its potential to boost testosterone levels in hypogonadal men.
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| Other Names | Zuclomiphene citrate, cis-Clomiphene citrate |
|---|---|
| IUPAC Name | 2-[4-[(Z)-2-chloro-1, 2-diphenylethenyl]phenoxy]-N, N-diethylethanamine;2-hydroxypropane-1, 2, 3-tricarboxylic acid |
| CAS | 7619-53-6 |
| Molecular Weight | 598.1 |
| Molecular Formula | C32H36ClNO8 |
| SMILES | CCN(CC)CCOC1=CC=C(C=C1)/C(=C(/C2=CC=CC=C2)\Cl)/C3=CC=CC=C3.C(C(=O)O)C(CC(=O)O)(C(=O)O)O |