Lodenafil, also known as hydroxyhomosildenafil, is a PDE5 inhibitor used for treating erectile dysfunction. It is formulated as a prodrug, lodenafil carbonate, which breaks down in the body to release two active lodenafil molecules, offering higher oral bioavailability.
Lodenafil has undergone Phase III clinical trials but is not yet approved by the U.S. FDA. It belongs to the same class as sildenafil, tadalafil, and vardenafil, with a chemical.
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| Other Names | Hydroxyhomo Sildenafil, hydroxyhomosildenafil |
|---|---|
| IUPAC Name | 5-[2-ethoxy-5-[4-(2-hydroxyethyl)piperazin-1-yl]sulfonylphenyl]-1-methyl-3-propyl-6H-pyrazolo[4, 3-d]pyrimidin-7-one |
| CAS | 139755-85-4 |
| Molecular Weight | 504.6 |
| Molecular Formula | C23H32N6O5S |
| SMILES | CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)CCO)OCC)C |