PRE-084 – (138847-85-5)

PRE-084 is a highly selective sigma-1 receptor (S1R). This compound has garnered significant attention in research due to its multifaceted therapeutic potential. PRE-084 exhibits notable neuroprotective properties, enhancing motor function and promoting motor neuron survival in mouse models. Additionally, it has been shown to mitigate myocardial ischemia-reperfusion injury in rats by activating the Akt-eNOS pathway.

In vitro studies indicate that PRE-084 protects cortical neurons against β-amyloid toxicity and reduces levels of the proapoptotic protein Bax. In vivo experiments further support its efficacy, showing improvements in motor performance and increased levels of brain-derived neurotrophic factor (BDNF) in the gray matter of wobbler mice. PRE-084’s ability to modulate multiple intracellular signaling mechanisms makes it a promising candidate for exploring treatments in neurological and cardiovascular diseases. Its chemical structure and pharmacological profile have been extensively studied, revealing its potential in cardioprotection, endothelial protection, and neuroprotection.

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Sources:

https://en.wikipedia.org/wiki/PRE-084
https://www.medchemexpress.com/pre-084.html
https://www.medkoo.com/products/11786
https://pubmed.ncbi.nlm.nih.gov/32668330/