SLU-PP-332 – (303760-60-3)

SLU-PP-332 is a potent pan-agonist for estrogen-related receptors (ERRs), with a particular affinity for ERRα. This compound has demonstrated significant potential in enhancing mitochondrial function and cellular respiration in skeletal muscle cell lines, making it a promising candidate for the study and treatment of metabolic diseases.

In mouse models of obesity and metabolic syndrome, SLU-PP-332 has been shown to mimic the benefits of physical exercise by increasing energy expenditure and fatty acid oxidation, while also reducing fat mass accumulation and improving insulin sensitivity. These findings suggest that pharmacological activation of ERRs with SLU-PP-332 could be an effective therapeutic strategy for managing metabolic disorders and improving muscle function, particularly in aging populations.

The above information is displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.

SLU-PP-332 is a potent pan-agonist for estrogen-related receptors (ERRs), with a particular affinity for ERRα. This compound has demonstrated significant potential in enhancing mitochondrial function and cellular respiration in skeletal muscle cell lines, making it a promising candidate for the study and treatment of metabolic diseases.

In mouse models of obesity and metabolic syndrome, SLU-PP-332 has been shown to mimic the benefits of physical exercise by increasing energy expenditure and fatty acid oxidation, while also reducing fat mass accumulation and improving insulin sensitivity. These findings suggest that pharmacological activation of ERRs with SLU-PP-332 could be an effective therapeutic strategy for managing metabolic disorders and improving muscle function, particularly in aging populations.

The above information is displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.

Sources:

https://en.wikipedia.org/wiki/SLU-PP-332
https://pubchem.ncbi.nlm.nih.gov/compound/5338394
https://www.medchemexpress.com/slu-pp-332.html
https://www.medkoo.com/products/53978
https://pubmed.ncbi.nlm.nih.gov/37739806/
https://www.sciencedirect.com/science/article/pii/S0306987724001051

IUPAC Name	4-hydroxy-N-[(E)-naphthalen-2-ylmethylideneamino]benzamide
CAS	303760-60-3
Molecular Weight	290.3
Molecular Formula	C18H14N2O2
SMILES	C1=CC=C2C=C(C=CC2=C1)/C=N/NC(=O)C3=CC=C(C=C3)O