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Teriparatide Acetate – (52232-67-4)
Teriparatide Acetate - (52232-67-4)

Teriparatide Acetate – (52232-67-4)

Teriparatide is a synthetic form of the human parathyroid hormone consisting of the first 34 amino acids, which is the biologically active portion of the hormone. It is an effective anabolic agent used in the research of osteoporosis in postmenopausal women, men with primary or hypogonadal osteoporosis, and individuals with osteoporosis associated with long-term systemic glucocorticoid therapy.

Teriparatide increases bone mineral density and reduces the risk of fragility fractures, particularly in the spine, by stimulating new bone formation. It is administered via subcutaneous injection and is contraindicated in patients with open epiphyses, metabolic bone diseases, Paget’s disease of bone, bone metastases, a history of skeletal malignancies, or prior radiation therapy involving the skeleton.

The drug’s mechanism of action involves intermittent exposure to PTH, which activates osteoblasts more than osteoclasts, leading to a net effect of stimulating new bone formation.

The above information is displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.

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Teriparatide is a synthetic form of the human parathyroid hormone consisting of the first 34 amino acids, which is the biologically active portion of the hormone. It is an effective anabolic agent used in the research of osteoporosis in postmenopausal women, men with primary or hypogonadal osteoporosis, and individuals with osteoporosis associated with long-term systemic glucocorticoid therapy.

Teriparatide increases bone mineral density and reduces the risk of fragility fractures, particularly in the spine, by stimulating new bone formation. It is administered via subcutaneous injection and is contraindicated in patients with open epiphyses, metabolic bone diseases, Paget’s disease of bone, bone metastases, a history of skeletal malignancies, or prior radiation therapy involving the skeleton.

The drug’s mechanism of action involves intermittent exposure to PTH, which activates osteoblasts more than osteoclasts, leading to a net effect of stimulating new bone formation.

The above information is displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.
Sources:
https://en.wikipedia.org/wiki/Teriparatide
https://pubchem.ncbi.nlm.nih.gov/compound/16129682
https://www.medchemexpress.com/Teriparatide.html
https://www.medkoo.com/products/48449
https://www.mayoclinic.org/drugs-supplements/teriparatide-subcutaneous-route/description/drg-20066280
https://my.clevelandclinic.org/health/drugs/19757-teriparatide-injection
Other Names

Teriparatide acetate hydrate, TERIPARATIDE RECOMBINANT HUMAN, EX-A7393, ZDA29494

IUPAC Name

4-[[2-[[2-[[4-amino-2-[[2-[[2-[[6-amino-2-[[2-[[2-[[4-amino-2-[[2-[[2-[[2-[[5-amino-2-[[2-[[2-[[2-[[2-[(2-amino-3-hydroxypropanoyl)amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-4-carboxybutanoyl]amino]-3-methylpentanoyl]amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-4-oxobutanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]hexanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-[[1-[[1-[[1-[[1-[[1-[[1-[[6-amino-1-[[6-amino-1-[[1-[[5-amino-1-[[1-[[1-[[1-[[4-amino-1-[(1-carboxy-2-phenylethyl)amino]-1, 4-dioxobutan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-1, 5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-oxopentanoic acid

CAS

52232-67-4

Molecular Weight

4118

Molecular Formula

C181H291N55O51S2

SMILES

CCC(C)C(C(=O)NC(CCC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(CCSC)C(=O)NC(CC1=CNC=N1)C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC2=CNC=N2)C(=O)NC(CC(C)C)C(=O)NC(CC(=O)N)C(=O)NC(CO)C(=O)NC(CCSC)C(=O)NC(CCC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(C(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)N)C(=O)NC(CC(=O)O)C(=O)NC(C(C)C)C(=O)NC(CC5=CNC=N5)C(=O)NC(CC(=O)N)C(=O)NC(CC6=CC=CC=C6)C(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CO)NC(=O)C(C(C)C)NC(=O)C(CO)N

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