BNC375 – (1557240-80-8)

BNC375 is a potent, selective, and orally available type I positive allosteric modulator of α7 nicotinic acetylcholine receptors (nAChRs). It exhibits good CNS-agent-like properties and clinical candidate potential.

BNC375 significantly potentiates the acetylcholine signal without altering rapid receptor desensitization. It has demonstrated efficacy in reversing scopolamine-induced cognitive impairment in mouse models. T

he compound has a plasma half-life of 1.2 hours and shows promising pharmacokinetic properties, including good oral bioavailability.

The above information is displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.

BNC375 is a potent, selective, and orally available type I positive allosteric modulator of α7 nicotinic acetylcholine receptors (nAChRs). It exhibits good CNS-agent-like properties and clinical candidate potential.

BNC375 significantly potentiates the acetylcholine signal without altering rapid receptor desensitization. It has demonstrated efficacy in reversing scopolamine-induced cognitive impairment in mouse models. T

he compound has a plasma half-life of 1.2 hours and shows promising pharmacokinetic properties, including good oral bioavailability.

The above informationis displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.

Sources:

https://pubchem.ncbi.nlm.nih.gov/substance/488233408
https://www.medchemexpress.com/bnc375.html
https://www.medkoo.com/products/32795
https://pmc.ncbi.nlm.nih.gov/articles/PMC6511964/
https://www.sciencedirect.com/science/article/abs/pii/S0022356524258808

Other Names	BNC-375, BNC 375
IUPAC Name	4-((1R, 3R)-3-(((5-chloro-2-methoxyphenyl)amino)methyl)-2, 2-dimethylcyclopropyl)benzenesulfonamide
CAS	1557240-80-8
Molecular Weight	394.914
Molecular Formula	C19H23ClN2O3S
SMILES	O=S(C1=CC=C([C@H]2C(C)(C)[C@@H]2CNC3=CC(Cl)=CC=C3OC)C=C1)(N)=O

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BNC375 – (1557240-80-8)

BNC375 is a potent, selective, and orally available type I positive allosteric modulator of α7 nicotinic acetylcholine receptors (nAChRs). It exhibits good CNS-agent-like properties and clinical candidate potential.

BNC375 significantly potentiates the acetylcholine signal without altering rapid receptor desensitization. It has demonstrated efficacy in reversing scopolamine-induced cognitive impairment in mouse models. T

he compound has a plasma half-life of 1.2 hours and shows promising pharmacokinetic properties, including good oral bioavailability.

The above informationis displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.

Sources:

https://pubchem.ncbi.nlm.nih.gov/substance/488233408
https://www.medchemexpress.com/bnc375.html
https://www.medkoo.com/products/32795
https://pmc.ncbi.nlm.nih.gov/articles/PMC6511964/
https://www.sciencedirect.com/science/article/abs/pii/S0022356524258808

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BNC375 – (1557240-80-8)

BNC375 is a potent, selective, and orally available type I positive allosteric modulator of α7 nicotinic acetylcholine receptors (nAChRs). It exhibits good CNS-agent-like properties and clinical candidate potential.

BNC375 significantly potentiates the acetylcholine signal without altering rapid receptor desensitization. It has demonstrated efficacy in reversing scopolamine-induced cognitive impairment in mouse models. T

he compound has a plasma half-life of 1.2 hours and shows promising pharmacokinetic properties, including good oral bioavailability.

The above informationis displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.

Sources:

https://pubchem.ncbi.nlm.nih.gov/substance/488233408 https://www.medchemexpress.com/bnc375.html https://www.medkoo.com/products/32795 https://pmc.ncbi.nlm.nih.gov/articles/PMC6511964/ https://www.sciencedirect.com/science/article/abs/pii/S0022356524258808

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https://pubchem.ncbi.nlm.nih.gov/substance/488233408
https://www.medchemexpress.com/bnc375.html
https://www.medkoo.com/products/32795
https://pmc.ncbi.nlm.nih.gov/articles/PMC6511964/
https://www.sciencedirect.com/science/article/abs/pii/S0022356524258808