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Colivelin – (867021-83-8)
Colivelin - (867021-83-8)

Colivelin – (867021-83-8)

Colivelin is a synthetic neuroprotective peptide derived from the humanin family, known for its potent long-term effects against neurodegenerative diseases. It exhibits neuroprotective properties by activating the STAT3 signaling pathway, which helps suppress neuronal death, reduce amyloid-beta (Aβ) deposition, and mitigate synaptic plasticity deficits.

Colivelin has shown promise in preclinical studies for treating conditions such as Alzheimer’s disease and ischemic brain injury. Its mechanism involves upregulating anti-apoptotic genes and promoting neuronal survival, making it a potential therapeutic candidate for neurodegenerative and ischemic conditions.

The above information is displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.

SKU: 867021-83-8
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Colivelin is a synthetic neuroprotective peptide derived from the humanin family, known for its potent long-term effects against neurodegenerative diseases. It exhibits neuroprotective properties by activating the STAT3 signaling pathway, which helps suppress neuronal death, reduce amyloid-beta (Aβ) deposition, and mitigate synaptic plasticity deficits.

Colivelin has shown promise in preclinical studies for treating conditions such as Alzheimer’s disease and ischemic brain injury. Its mechanism involves upregulating anti-apoptotic genes and promoting neuronal survival, making it a potential therapeutic candidate for neurodegenerative and ischemic conditions.

The above informationis displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.
Sources:
https://pubchem.ncbi.nlm.nih.gov/compound/90477169
https://www.medchemexpress.com/Colivelin.html
https://pubmed.ncbi.nlm.nih.gov/31374230/
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.984298/full
https://www.nature.com/articles/1301591
Other Names

Colivelin TFA, Colivelin?, s9664

IUPAC Name

(2S)-1-[(2S)-2-[[(2S)-2-[[(2S, 3S)-2-[[(2S)-2-[[2-[[(2S, 3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-1-[(2S, 3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]propanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbonyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]propanoyl]amino]acetyl]amino]propanoyl]amino]-3-hydroxypropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]-4-carboxybutanoyl]amino]-3-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carboxylic acid

CAS

867021-83-8

Molecular Weight

2645.1

Molecular Formula

C119H206N32O35

SMILES

CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@@H]3CCCN3C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)N

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