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Decapeptide-12 – (137665-91-9)
Decapeptide-12 - (137665-91-9)

Decapeptide-12 – (137665-91-9)

Decapeptide-12 is a synthetic oligopeptide, known for its inhibitory activity against tyrosinase, an enzyme involved in melanin production, making it effective in reducing hyperpigmentation.

Decapeptide-12 has been studied for its potential in treating skin conditions like melasma and photoaging. It is a competitive inhibitor of mushroom tyrosinase. The peptide also increases transcription of SIRT genes, which are associated with anti-aging and anti-inflammatory effects.

Decapeptide-12 is used in research related to melanogenesis, senescence, and inflammation. Its structure includes multiple amino acids, and it is often modified to enhance skin penetration and retention, such as through palmitoylation to increase lipophilicity. Studies have shown its efficacy in reducing melanin content in melanocytes without affecting cell proliferation.

The above information is displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.

SKU: 137665-91-9
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Decapeptide-12 is a synthetic oligopeptide, known for its inhibitory activity against tyrosinase, an enzyme involved in melanin production, making it effective in reducing hyperpigmentation.

Decapeptide-12 has been studied for its potential in treating skin conditions like melasma and photoaging. It is a competitive inhibitor of mushroom tyrosinase. The peptide also increases transcription of SIRT genes, which are associated with anti-aging and anti-inflammatory effects.

Decapeptide-12 is used in research related to melanogenesis, senescence, and inflammation. Its structure includes multiple amino acids, and it is often modified to enhance skin penetration and retention, such as through palmitoylation to increase lipophilicity. Studies have shown its efficacy in reducing melanin content in melanocytes without affecting cell proliferation.

The above informationis displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.
Sources:
https://pubchem.ncbi.nlm.nih.gov/compound/25087629
https://www.medchemexpress.com/decapeptide-12.html
https://www.sciencedirect.com/science/article/abs/pii/S0378517321006736
https://pubmed.ncbi.nlm.nih.gov/22401652/
Other Names

DA-52389

IUPAC Name

2-[[2-[[2-[[2-[[2-[[6-amino-2-[[2-[[2-[[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-hydroxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoic acid

CAS

137665-91-9

Molecular Weight

1395.5

Molecular Formula

C65H90N18O17

SMILES

C1=CC=C2C(=C1)C(=CN2)CC(C(=O)NC(CC3=CC=C(C=C3)O)C(=O)O)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CCCCN)NC(=O)C(CCCN=C(N)N)NC(=O)C(CO)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC5=CC=C(C=C5)O)N

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