0
Home
Products
Dermorphin – (77614-16-5)
Dermorphin - (77614-16-5)

Dermorphin – (77614-16-5)

Dermorphin is a natural heptapeptide and a potent µ-opioid receptor (MOR) agonist, first isolated from the skin of South American frogs belonging to the genus *Phyllomedusa*.

It exhibits high selectivity and potency for mu-opioid receptors, making it approximately 30–40 times more potent than morphine. Dermorphin’s amino acid sequence is H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2.

Unlike typical peptides, it contains a D-alanine residue, which is not encoded by the genetic code and is synthesized through an unusual post-translational modification process involving an amino acid isomerase. T

his peptide is not found in humans or other mammals and has been primarily identified in bacteria, amphibians, and mollusks. Dermorphin has been illicitly used in horse racing as a performance-enhancing drug due to its potent painkilling effects.

The above information is displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.

SKU: 77614-16-5
Categories: , ,
Tags: , ,

Dermorphin is a natural heptapeptide and a potent µ-opioid receptor (MOR) agonist, first isolated from the skin of South American frogs belonging to the genus *Phyllomedusa*.

It exhibits high selectivity and potency for mu-opioid receptors, making it approximately 30–40 times more potent than morphine. Dermorphin’s amino acid sequence is H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2.

Unlike typical peptides, it contains a D-alanine residue, which is not encoded by the genetic code and is synthesized through an unusual post-translational modification process involving an amino acid isomerase. T

his peptide is not found in humans or other mammals and has been primarily identified in bacteria, amphibians, and mollusks. Dermorphin has been illicitly used in horse racing as a performance-enhancing drug due to its potent painkilling effects.

The above information is displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.
Sources:
https://en.wikipedia.org/wiki/Dermorphin
https://pubchem.ncbi.nlm.nih.gov/compound/5485199
https://www.medchemexpress.com/Dermorphin.html
https://pmc.ncbi.nlm.nih.gov/articles/PMC6260176/
https://www.sciencedirect.com/topics/neuroscience/dermorphin
Other Names

H-Tyr-D-ala-phe-gly-tyr-pro-ser-NH2, (2S)-N-[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]-1-[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carboxamide, Tyrosyl-alanyl-phenylalanyl-glycyl-tyrosyl-prolyl-serinamide

IUPAC Name

(2S)-N-[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]-1-[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carboxamide

CAS

77614-16-5

Molecular Weight

802.9

Molecular Formula

C40H50N8O10

SMILES

C[C@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CO)C(=O)N)NC(=O)[C@H](CC4=CC=C(C=C4)O)N

Related products

No products in the cart.