0
Home
Products
DSIP – (62568-57-4)
DSIP - (62568-57-4)

DSIP – (62568-57-4)

Delta-sleep-inducing peptide (DSIP) is a neuropeptide first isolated in 1977 from rabbit brain. It is a nonapeptide with the amino acid sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu.

DSIP is known for its role in promoting sleep, particularly slow-wave sleep (SWS), and has been shown to induce delta EEG activity and reduce motor activity in rabbits. Despite its sleep-inducing properties, the exact mechanism of action, precursor peptide, and receptor for DSIP remain unidentified.

DSIP has been found in various tissues, including the hypothalamus, limbic system, pituitary, and peripheral organs, and is thought to interact with NMDA receptors and other neurochemical pathways. It has also been implicated in stress regulation, endocrine modulation, and potential therapeutic applications for conditions like insomnia, epilepsy, and withdrawal syndromes.

The above information is displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.

SKU: 62568-57-4
Category:
Tags: , , ,

Delta-sleep-inducing peptide (DSIP) is a neuropeptide first isolated in 1977 from rabbit brain. It is a nonapeptide with the amino acid sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu.

DSIP is known for its role in promoting sleep, particularly slow-wave sleep (SWS), and has been shown to induce delta EEG activity and reduce motor activity in rabbits. Despite its sleep-inducing properties, the exact mechanism of action, precursor peptide, and receptor for DSIP remain unidentified.

DSIP has been found in various tissues, including the hypothalamus, limbic system, pituitary, and peripheral organs, and is thought to interact with NMDA receptors and other neurochemical pathways. It has also been implicated in stress regulation, endocrine modulation, and potential therapeutic applications for conditions like insomnia, epilepsy, and withdrawal syndromes.

The above informationis displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.

Sources:
https://en.wikipedia.org/wiki/Delta-sleep-inducing_peptide
https://www.medchemexpress.com/_delta_-Sleep_Inducing_Peptide.html
https://journals.lww.com/ejanaesthesiology/fulltext/2001/07000/delta_sleep_inducing_peptide.1.aspx
https://www.sciencedirect.com/topics/neuroscience/delta-sleep-inducing-peptide
Other Names

Emideltide, DELTA SLEEP INDUCING PEPTIDE, DSIP nonapeptide

IUPAC Name

(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-[[(2S)-2-amino-3-(1H-indol-3-yl)propanoyl]amino]propanoyl]amino]acetyl]amino]acetyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]-3-hydroxypropanoyl]amino]acetyl]amino]pentanedioic acid

CAS

62568-57-4

Molecular Weight

848.8

Molecular Formula

C35H48N10O15

SMILES

C[C@@H](C(=O)NCC(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)O)NC(=O)[C@H](CC1=CNC2=CC=CC=C21)N

Related products

No products in the cart.