E1R, Methylphenylpiracetam – (1301211-78-8)

Methylphenylpiracetam is a derivative of piracetam and a positive allosteric modulator of the sigma-1 receptor. It differs from phenylpiracetam by the addition of a methyl group. The (4R,5S) stereoisomer, known as E1R, is the most active form, showing significant cognition-enhancing effects without affecting locomotor activity. E1R has demonstrated efficacy in alleviating scopolamine-induced cognitive impairment in mice and enhancing memory retention.

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Sources:

https://en.wikipedia.org/wiki/Methylphenylpiracetam
https://www.medchemexpress.com/e1r.html
https://www.medkoo.com/products/16087
https://pubmed.ncbi.nlm.nih.gov/24490863/