Exemestane is a molecule used to treat breast cancer in postmenopausal women. It belongs to the class of molecules known as aromatase inhibitors, which work by reducing the production of estrogen in the body. This is particularly effective for estrogen receptor-positive breast cancers, as these cancers rely on estrogen to grow.
Exemestane is metabolized by the liver enzyme CYP3A4, and its effectiveness can be reduced by strong CYP3A4 inducers like rifampicin.
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| Other Names | Aromasin, 6-Methyleneandrosta-1, 4-diene-3, 17-dione, Aromasine |
|---|---|
| IUPAC Name | (8R, 9S, 10R, 13S, 14S)-10, 13-dimethyl-6-methylidene-7, 8, 9, 11, 12, 14, 15, 16-octahydrocyclopenta[a]phenanthrene-3, 17-dione |
| CAS | 107868-30-4 |
| Molecular Weight | 296.4 |
| Molecular Formula | C20H24O2 |
| SMILES | C[C@]12CC[C@H]3[C@H]([C@@H]1CCC2=O)CC(=C)C4=CC(=O)C=C[C@]34C |