Fladrafinil (CRL-40,941) – (90212-80-9)

Fladrafinil, also known as fluorafinil or CRL-40,941, is a wakefulness-promoting agent and nootropic compound structurally related to modafinil. Despite its potential cognitive-enhancing properties, fladrafinil has never been marketed as a pharmaceutical drug. It is a derivative of adrafinil, with two fluorine atoms substituted on the phenyl rings, and is purported to be 3 to 4 times more potent than its parent compound in terms of anti-aggressive effects.

Research on fladrafinil is limited, but studies have investigated its thermal degradation and potential for analysis-related ambiguities in forensic and clinical settings. The compound has been shown to degrade under heat, forming degradation products such as 1,1,2,2-tetraphenylethane and its fluorinated analog, which can complicate analytical procedures.

The above information is displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.

Fladrafinil, also known as fluorafinil or CRL-40,941, is a wakefulness-promoting agent and nootropic compound structurally related to modafinil. Despite its potential cognitive-enhancing properties, fladrafinil has never been marketed as a pharmaceutical drug. It is a derivative of adrafinil, with two fluorine atoms substituted on the phenyl rings, and is purported to be 3 to 4 times more potent than its parent compound in terms of anti-aggressive effects.

Research on fladrafinil is limited, but studies have investigated its thermal degradation and potential for analysis-related ambiguities in forensic and clinical settings. The compound has been shown to degrade under heat, forming degradation products such as 1,1,2,2-tetraphenylethane and its fluorinated analog, which can complicate analytical procedures.

The above information is displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.

Sources:

https://en.wikipedia.org/wiki/Fladrafinil
https://pubchem.ncbi.nlm.nih.gov/compound/13316557
https://www.medkoo.com/products/42718
https://pubmed.ncbi.nlm.nih.gov/27928893/
https://www.researchgate.net/publication/311496510_Outsmarted_by_nootropics_An_investigation_into_the_thermal_degradation_of_modafinil_modafinic_acid_adrafinil_CRL-40940_and_CRL-40941_in_the_GC_injector_formation_of_1122-tetraphenylethane_and_its_tetr

Other Names	Fluorafinil, CRL-40, 941
IUPAC Name	2-[bis(4-fluorophenyl)methylsulfinyl]-N-hydroxyacetamide
CAS	90212-80-9
Molecular Weight	325.3
Molecular Formula	C15H13F2NO3S
SMILES	C1=CC(=CC=C1C(C2=CC=C(C=C2)F)S(=O)CC(=O)NO)F