MRK-016 – (342652-67-9)

MRK-016 is a selective inverse agonist of the GABA α5 receptor. In vivo studies indicate that MRK-016 improves performance in hippocampal-dependent memory tasks and protects against LPS-induced learning and memory deficits in mice without causing seizures or anxiogenic effects at tested doses. Despite its promising cognitive-enhancing properties and favorable safety profile in young males, MRK-016’s development was halted due to poor tolerability in elderly subjects and variable human pharmacokinetics.

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Sources:

https://en.wikipedia.org/wiki/MRK-016
https://www.medchemexpress.com/MRK-016.html
https://www.medkoo.com/products/9035
https://pubmed.ncbi.nlm.nih.gov/19704033/