Norbinaltorphimine, commonly known as nor-BNI or nBNI, is a potent opioid antagonist primarily used in scientific research. It is renowned for its high selectivity as an inverse agonist for the κ-opioid receptor, making it a valuable tool in studying the κ-opioid system.
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| Other Names | nor-Binaltorphimine, Nor-bni, NorBNI |
|---|---|
| IUPAC Name | (1S, 2S, 7S, 8S, 12R, 20R, 24R, 32R)-11, 33-bis(cyclopropylmethyl)-19, 25-dioxa-11, 22, 33-triazaundecacyclo[24.9.1.18, 14.01, 24.02, 32.04, 23.05, 21.07, 12.08, 20.030, 36.018, 37]heptatriaconta-4(23), 5(21), 14(37), 15, 17, 26, 28, 30(36)-octaene-2, 7, 17, 27-tetrol |
| CAS | 105618-26-6 |
| Molecular Weight | 661.8 |
| Molecular Formula | C40H43N3O6 |
| SMILES | C1CC1CN2CC[C@]34[C@@H]5C6=C(C[C@]3([C@H]2CC7=C4C(=C(C=C7)O)O5)O)C8=C(N6)[C@H]9[C@@]12CCN([C@@H]([C@@]1(C8)O)CC1=C2C(=C(C=C1)O)O9)CC1CC1 |