p-F-Deprenyl (racemic) – (103596-31-2)

p-F-Deprenyl is a molecule derived from selegiline, featuring a fluorine atom at the 4-position of the molecule. This compound acts as a selective and irreversible inhibitor of monoamine oxidase B (MAO-B), enhancing monoaminergic activity. Its pharmacological profile is similar to selegiline, but with distinct characteristics due to the fluorine substitution.

In clinical settings, a radiolabelled derivative of 4-Fluoroselegiline, incorporating 18F, is utilized to investigate MAO-B inhibition in both in vivo and in vitro experiments. This application highlights its potential in neurological research and drug development. The compound’s ability to enhance catecholaminergic activity while diminishing serotoninergic activity in the brain further underscores its unique pharmacological properties, which are not solely attributable to MAO-B inhibition.

Despite its promising characteristics, p-F-Deprenyl remains an abandoned drug, with limited clinical data available. Its chemical structure and pharmacological features, however, continue to be of interest in the field of neuroscience, particularly in the study of neurodegenerative disorders.

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Sources:

https://en.wikipedia.org/wiki/4-Fluoroselegiline
https://pubmed.ncbi.nlm.nih.gov/7995016/
https://pubmed.ncbi.nlm.nih.gov/10872569/
https://www.sciencedirect.com/science/article/abs/pii/S0161813X03001025