RH-34 – (1028307-48-3)

RH-34 is a potent and selective partial agonist for the 5-HT2A serotonin receptor subtype, developed through structural modification of the selective 5-HT2A antagonist ketanserin. This compound replaces the 4-(p-fluorobenzoyl)piperidine moiety of ketanserin with the N-(2-methoxybenzyl) pharmacophore found in potent 5-HT2A agonists like NBOMe-2C-B and NBOMe-2C-I. This alteration maintains 5-HT2A affinity and selectivity but shifts the activity from antagonism to a moderate efficacy partial agonist.

The above information is displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.

RH-34 is a potent and selective partial agonist for the 5-HT2A serotonin receptor subtype, developed through structural modification of the selective 5-HT2A antagonist ketanserin. This compound replaces the 4-(p-fluorobenzoyl)piperidine moiety of ketanserin with the N-(2-methoxybenzyl) pharmacophore found in potent 5-HT2A agonists like NBOMe-2C-B and NBOMe-2C-I. This alteration maintains 5-HT2A affinity and selectivity but shifts the activity from antagonism to a moderate efficacy partial agonist.

The above information is displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.

Sources:

https://en.wikipedia.org/wiki/RH-34
https://pubchem.ncbi.nlm.nih.gov/compound/10041987
https://www.medchemexpress.com/5-ht2a-receptor-agonist-6.html
https://www.medkoo.com/products/59925
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1423-0410.1991.tb00257.x
https://www.sciencedirect.com/science/article/pii/S0006497120513839

Other Names	A31AED225O
IUPAC Name	3-[2-[(2-methoxyphenyl)methylamino]ethyl]-1H-quinazoline-2, 4-dione
CAS	1028307-48-3
Molecular Weight	325.4
Molecular Formula	C18H19N3O3
SMILES	COC1=CC=CC=C1CNCCN2C(=O)C3=CC=CC=C3NC2=O