RTI-336 free base – (236754-02-2)

RTI-336 is a phenyltropane derivative that acts as a potent and selective dopamine reuptake inhibitor and stimulant drug. It binds to the dopamine transporter with approximately 20 times the affinity of cocaine, yet it produces relatively mild stimulant effects with a slow onset and long duration of action. These characteristics make RTI-336 a potential candidate for treating cocaine addiction, as it could serve as a substitute drug similar to how methadone is used for treating heroin abuse. In preclinical studies, RTI-336 has been shown to fully substitute for cocaine in addicted monkeys and support self-administration, significantly reducing cocaine use, particularly when combined with SSRIs. Research is ongoing to determine its viability as a substitute drug in human cocaine addicts.

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Sources:

https://en.wikipedia.org/wiki/RTI-336
https://pubchem.ncbi.nlm.nih.gov/compound/9800708
https://pmc.ncbi.nlm.nih.gov/articles/PMC2751440/
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2018.00712/full
https://www.researchgate.net/publication/44802656_Lower_reinforcing_strength_of_the_phenyltropane_cocaine_analogs_RTI-336_and_RTI-177_compared_to_cocaine_in_nonhuman_primates