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Selank – (129954-34-3)
Selank - (129954-34-3)

Selank – (129954-34-3)

Selank is a synthetic heptapeptide developed by the Institute of Molecular Genetics of the Russian Academy of Sciences. It is an analogue of the immunomodulatory peptide tuftsin and exhibits anxiolytic and nootropic properties. Selank is known for its ability to modulate the expression of Interleukin-6 (IL-6) and affect the balance of T helper cell cytokines. It influences the concentration of monoamine neurotransmitters and induces the metabolism of serotonin. Additionally, Selank rapidly elevates the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus of rats.

In clinical trials, Selank has demonstrated a sustained nootropic and anxiolytic effect, making it a potential treatment for generalized anxiety disorder (GAD). Unlike traditional anxiety treatments such as benzodiazepines, Selank does not cause sedation, cognitive impairment, addiction, or withdrawal symptoms.

Selank’s mechanism of action involves inhibiting enzymes that degrade enkephalins and other endogenous regulatory peptides, which may contribute to its effects. It also affects the activity of carboxypeptidase H and phenylmethylsulfonylfluoride-inhibited carboxypeptidase in rat nervous system tissue. Studies have shown that Selank produces antidepressant-like effects in animal models of depression and anhedonia.

The above information is displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.

SKU: 129954-34-3
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Selank is a synthetic heptapeptide developed by the Institute of Molecular Genetics of the Russian Academy of Sciences. It is an analogue of the immunomodulatory peptide tuftsin and exhibits anxiolytic and nootropic properties. Selank is known for its ability to modulate the expression of Interleukin-6 (IL-6) and affect the balance of T helper cell cytokines. It influences the concentration of monoamine neurotransmitters and induces the metabolism of serotonin. Additionally, Selank rapidly elevates the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus of rats.

In clinical trials, Selank has demonstrated a sustained nootropic and anxiolytic effect, making it a potential treatment for generalized anxiety disorder (GAD). Unlike traditional anxiety treatments such as benzodiazepines, Selank does not cause sedation, cognitive impairment, addiction, or withdrawal symptoms.

Selank’s mechanism of action involves inhibiting enzymes that degrade enkephalins and other endogenous regulatory peptides, which may contribute to its effects. It also affects the activity of carboxypeptidase H and phenylmethylsulfonylfluoride-inhibited carboxypeptidase in rat nervous system tissue. Studies have shown that Selank produces antidepressant-like effects in animal models of depression and anhedonia.

The above information is displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.
Sources:
https://en.wikipedia.org/wiki/Selank
https://pubchem.ncbi.nlm.nih.gov/compound/11765600
https://www.medchemexpress.com/selank.html
https://www.medkoo.com/products/23959
https://pmc.ncbi.nlm.nih.gov/articles/PMC4757669/
Other Names

Selanc, Thr-Lys-Pro-Arg-Pro-Gly-Pro, TP-7

IUPAC Name

(2S)-1-[2-[[(2S)-1-[(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S, 3R)-2-amino-3-hydroxybutanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]acetyl]pyrrolidine-2-carboxylic acid

CAS

129954-34-3

Molecular Weight

751.9

Molecular Formula

C33H57N11O9

SMILES

C[C@H]([C@@H](C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N2CCC[C@H]2C(=O)NCC(=O)N3CCC[C@H]3C(=O)O)N)O

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