Tianeptine – (66981-73-5)

Tianeptine is an atypical tricyclic antidepressant. Unlike traditional tricyclic antidepressants, tianeptine enhances serotonin reuptake rather than inhibiting it, which contributes to its unique pharmacological profile. It also acts as a full agonist at the mu-opioid receptor, producing effects similar to opioids, including euphoria and potential for abuse.

The drug is known for its efficacy in reducing depressive symptoms and alleviating anxiety, particularly in panic disorders. Tianeptine exhibits neuroprotective properties and has been shown to improve cognitive function in patients with depression. Its mechanism of action involves modulating glutamate and glutamatergic systems, which is thought to contribute to its antidepressant effects.

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Sources:

https://en.wikipedia.org/wiki/Tianeptine
https://pubchem.ncbi.nlm.nih.gov/compound/68870
https://psychonautwiki.org/wiki/Tianeptine
https://pmc.ncbi.nlm.nih.gov/articles/PMC10444703/
https://www.sciencedirect.com/topics/neuroscience/tianeptine