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FRAGMENT 176-191 – (66004-57-7)
Human Growth Hormone Fragment 176–191 (hGH frag 176–191) is a synthetic peptide derived from the C-terminus of human growth hormone. It is primarily known for its potential lipolytic properties, making it a subject of interest in obesity research.
Unlike full-length hGH, which promotes growth and has various metabolic effects, hGH frag 176–191 is believed to specifically target fat metabolism without significantly impacting carbohydrate metabolism or insulin-like growth factor 1 (IGF-1) levels. Studies in animal models suggest that this peptide may enhance fat loss by stimulating lipolysis in adipocytes and increasing skeletal muscle thermogenesis.
Additionally, research indicates that hGH frag 176–191 could potentially aid in cartilage regeneration and improve the efficacy of hyaluronic acid in treating osteoarthritis. Importantly, this peptide is thought to avoid the negative side effects associated with hGH supplementation, such as insulin resistance and impaired glucose tolerance. While promising, hGH frag 176–191 is currently used only in research settings and has not yet received medical approval for clinical use.
The above information is displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.
https://en.wikipedia.org/wiki/HGH_Fragment_176%E2%80%93191
| Other Names | Somatotropin (176-191), Hgh (176-191) |
|---|---|
| IUPAC Name | [(2S)-2-[[(2S, 3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylpentanoyl]amino]-3-methylbutanoyl] (4S)-5-[[2-[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-3-sulfanylpropanoyl]amino]acetyl]amino]-3-phenylpropanoyl]oxy-2-oxoethyl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-5-carbamimidamido-2-[[(2R)-2-[[(2S)-2, 5-diamino-5-oxopentanoyl]amino]-3-sulfanylidenepropanoyl]amino]pentanoyl]amino]-3-hydroxypropanoyl]amino]-3-methylbutanoyl]amino]-5-oxopentanoate |
| CAS | 66004-57-7 |
| Molecular Weight | 1799.1 |
| Molecular Formula | C78H123N23O22S2 |
| SMILES | CC[C@H](C)[C@@H](C(=O)N[C@@H](C(C)C)C(=O)OC(=O)CC[C@@H](C(=O)NCC(=O)OC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@H](CO)N)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C=S)NC(=O)[C@H](CCC(=O)N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC2=CC=CC=C2)N |
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