Thymosin alpha-1 - (62304-98-7)

Thymosin alpha-1 – (62304-98-7)

Thymosin alpha 1 is a 28-amino acid peptide initially isolated from the thymus gland, recognized for its immune-enhancing properties. It plays a crucial role in the immune system by promoting T-cell maturation and differentiation, activating dendritic and natural killer cells, and stimulating cytokine-mediated inflammation.

Thymosin alpha 1 exhibits a wide range of biological activities, including anti-tumor effects and immune modulation. It enhances the immune response by increasing the activity of T cells, natural killer cells, and CD8+ T cells, which are essential for fighting viral, bacterial, and fungal infections, as well as cancers. Additionally, it has been shown to increase the production of interleukins (IL-2, IL-10, IL-12), interferons (IFN-α, IFN-γ), and other cytokines, further supporting its role in immune function.

Clinically, thymosin alpha 1 has been used in the treatment of chronic hepatitis B and C, where it has demonstrated efficacy in improving virological response rates when used in combination with other therapies. It has also been investigated for its potential in treating sepsis, HIV infection, and various types of cancer, including hepatocellular carcinoma, lung cancer, and melanoma. In the context of COVID-19, thymosin alpha 1 has been explored for its ability to mitigate the cytokine storm and improve T-cell counts in severely ill patients, showing promising results in preliminary studies.

The above information is displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.

SKU: 62304-98-7

Category: Biological peptide

Tags: Antiviral agent, Immune response modulator, Immunostimulatory peptide, T-cell differentiation enhancer

Description
Additional information

Thymosin alpha 1 is a 28-amino acid peptide initially isolated from the thymus gland, recognized for its immune-enhancing properties. It plays a crucial role in the immune system by promoting T-cell maturation and differentiation, activating dendritic and natural killer cells, and stimulating cytokine-mediated inflammation.

Thymosin alpha 1 exhibits a wide range of biological activities, including anti-tumor effects and immune modulation. It enhances the immune response by increasing the activity of T cells, natural killer cells, and CD8+ T cells, which are essential for fighting viral, bacterial, and fungal infections, as well as cancers. Additionally, it has been shown to increase the production of interleukins (IL-2, IL-10, IL-12), interferons (IFN-α, IFN-γ), and other cytokines, further supporting its role in immune function.

Clinically, thymosin alpha 1 has been used in the treatment of chronic hepatitis B and C, where it has demonstrated efficacy in improving virological response rates when used in combination with other therapies. It has also been investigated for its potential in treating sepsis, HIV infection, and various types of cancer, including hepatocellular carcinoma, lung cancer, and melanoma. In the context of COVID-19, thymosin alpha 1 has been explored for its ability to mitigate the cytokine storm and improve T-cell counts in severely ill patients, showing promising results in preliminary studies.

The above information is displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.

Sources:

https://en.wikipedia.org/wiki/Thymosin_%CE%B11
https://pubchem.ncbi.nlm.nih.gov/compound/16130571
https://www.medchemexpress.com/Thymalfasin.html
https://pmc.ncbi.nlm.nih.gov/articles/PMC7747025/
https://www.sciencedirect.com/topics/medicine-and-dentistry/thymosin-alpha1

Other Names	Thymalfasin, Zadaxin
IUPAC Name	(4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S, 3R)-2-[[(2S, 3R)-2-[[(2S, 3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S, 3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]propanoyl]amino]-3-methylbutanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-4-carboxybutanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxybutanoyl]amino]-6-aminohexanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoyl]amino]-6-aminohexanoyl]amino]-4-carboxybutanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanoyl]amino]-4-carboxybutanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-4-carboxybutanoyl]amino]-4-carboxybutanoyl]amino]propanoyl]amino]-5-[[(1S)-3-amino-1-carboxy-3-oxopropyl]amino]-5-oxopentanoic acid
CAS	62304-98-7
Molecular Weight	3108.3
Molecular Formula	C129H215N33O55
SMILES	CC[C@H](C)[C@@H](C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)C

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