Ziconotide Acetate - (107452-89-1)

Ziconotide Acetate – (107452-89-1)

Ziconotide is a synthetic peptide derived from the venom of the cone snail Conus magus. It is a potent and selective N-type voltage-gated calcium channel blocker, primarily used for the management of severe chronic pain in patients who are intolerant or refractory to other treatments.

The drug’s mechanism of action involves blocking N-type calcium channels in the dorsal horn of the spinal cord, which inhibits the release of neurotransmitters such as glutamate, substance P, and calcitonin gene-related peptide. This blockade disrupts the transmission of pain signals, providing significant analgesic effects without the risk of addiction or tolerance associated with opioid-based therapies.

The above information is displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.

SKU: 107452-89-1

Categories: Biochemical, Pharmaceutical intermediate

Description
Additional information

Ziconotide is a synthetic peptide derived from the venom of the cone snail Conus magus. It is a potent and selective N-type voltage-gated calcium channel blocker, primarily used for the management of severe chronic pain in patients who are intolerant or refractory to other treatments.

The drug’s mechanism of action involves blocking N-type calcium channels in the dorsal horn of the spinal cord, which inhibits the release of neurotransmitters such as glutamate, substance P, and calcitonin gene-related peptide. This blockade disrupts the transmission of pain signals, providing significant analgesic effects without the risk of addiction or tolerance associated with opioid-based therapies.

The above information is displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.

Sources:

https://en.wikipedia.org/wiki/Ziconotide
https://pubchem.ncbi.nlm.nih.gov/compound/16135415
https://www.medchemexpress.com/ziconotide.html
https://synapse.patsnap.com/article/what-is-ziconotide-acetate-used-for
https://drugs.ncats.io/drug/T2I226K69M
https://www.sciencedirect.com/topics/chemistry/ziconotide

Other Names	Prialt, SNX-111
IUPAC Name	2-[(1R, 4S, 7S, 13S, 16R, 21R, 24S, 27S, 30S, 33S, 36S, 39S, 42R, 45S, 48S, 54S, 60S, 63R, 68R, 71S, 77S)-63-amino-13, 45, 54, 60-tetrakis(4-aminobutyl)-4, 36-bis(3-carbamimidamidopropyl)-16-carbamoyl-71-[(1R)-1-hydroxyethyl]-7, 39, 77-tris(hydroxymethyl)-27-[(4-hydroxyphenyl)methyl]-48-methyl-33-(2-methylpropyl)-30-(2-methylsulfanylethyl)-2, 5, 8, 11, 14, 23, 26, 29, 32, 35, 38, 41, 44, 47, 50, 53, 56, 59, 62, 69, 72, 75, 78, 85-tetracosaoxo-18, 19, 65, 66, 81, 82-hexathia-3, 6, 9, 12, 15, 22, 25, 28, 31, 34, 37, 40, 43, 46, 49, 52, 55, 58, 61, 70, 73, 76, 79, 84-tetracosazatricyclo[40.37.4.221, 68]pentaoctacontan-24-yl]acetic acid
CAS	107452-89-1
Molecular Weight	2639.2
Molecular Formula	C102H172N36O32S7
SMILES	C[C@H]1C(=O)N[C@H](C(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N1)CCCCN)CCCCN)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N3)CO)[C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC2=O)CO)CCCNC(=N)N)CC(C)C)CCSC)CC4=CC=C(C=C4)O)CC(=O)O)C(=O)N)CCCCN)CO)CCCNC(=N)N)CCCCN

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