Eutropoflavin – (1205548-04-4)

Eutropoflavin (4′-Dimethylamino-7,8-dihydroxyflavone) is a synthetic flavone and selective small-molecule agonist of TrkB, the main receptor of brain-derived neurotrophic factor (BDNF). It was derived from structural modification of tropoflavin (7,8-DHF).

Eutropoflavin exhibits higher agonistic activity at TrkB, greater potency in vitro and in vivo, and a longer duration of action compared to tropoflavin, peaking at 4 hours and partially decaying at 8-16 hours in rodents. The compound demonstrates neuroprotective, neurogenic, and antidepressant-like effects in animal studies.

The above information is displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.

Eutropoflavin (4′-Dimethylamino-7,8-dihydroxyflavone) is a synthetic flavone and selective small-molecule agonist of TrkB, the main receptor of brain-derived neurotrophic factor (BDNF). It was derived from structural modification of tropoflavin (7,8-DHF).

Eutropoflavin exhibits higher agonistic activity at TrkB, greater potency in vitro and in vivo, and a longer duration of action compared to tropoflavin, peaking at 4 hours and partially decaying at 8-16 hours in rodents. The compound demonstrates neuroprotective, neurogenic, and antidepressant-like effects in animal studies.

The above informationis displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.
Sources:
https://en.wikipedia.org/wiki/Eutropoflavin
https://dbpedia.org/page/Eutropoflavin
Other Names

2-(4-(Dimethylamino)phenyl)-7, 8-dihydroxy-4H-chromen-4-one 4'-Dimethylamino 7, 8-Dihydroxyflavone, B2M862MR4W

IUPAC Name

2-(4-(Dimethylamino)phenyl)-7, 8-dihydroxy-4H-chromen-4-one, B2M862MR4W

CAS

1205548-04-4

Molecular Weight

297.3

Molecular Formula

C17H15NO4

SMILES

CN(C)C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C=C3)O)O

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