Rimegepant sulfate – (1374024-48-2)

Rimegepant is a medication used for the acute treatment of migraine with or without aura in adults and for the preventive treatment of episodic migraine in adults. It is administered orally, dissolving on or under the tongue. Rimegepant functions as a calcitonin gene-related peptide (CGRP) receptor antagonist, effectively blocking CGRP receptors to provide relief from migraine symptoms.

In terms of its mechanism of action, rimegepant is a small molecule that selectively targets CGRP receptors, which are believed to play a key role in the pathophysiology of migraine. Clinical trials have demonstrated its efficacy and safety, with a favorable tolerability profile and no significant vasoconstrictive effects.

The above information is displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.

Rimegepant is a medication used for the acute treatment of migraine with or without aura in adults and for the preventive treatment of episodic migraine in adults. It is administered orally, dissolving on or under the tongue. Rimegepant functions as a calcitonin gene-related peptide (CGRP) receptor antagonist, effectively blocking CGRP receptors to provide relief from migraine symptoms.

In terms of its mechanism of action, rimegepant is a small molecule that selectively targets CGRP receptors, which are believed to play a key role in the pathophysiology of migraine. Clinical trials have demonstrated its efficacy and safety, with a favorable tolerability profile and no significant vasoconstrictive effects.

The above information is displayed for information purpose only, and has not been reviewed by EON nor does EON attests or validates the accuracy nor does it constitutes a recommendation or validation.

Sources:

https://en.wikipedia.org/wiki/Rimegepant
https://pubchem.ncbi.nlm.nih.gov/compound/71586738
https://www.medkoo.com/products/40721
https://pubmed.ncbi.nlm.nih.gov/36739335/
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/rimegepant

Other Names	Nurtec ODT
IUPAC Name	[(5S, 6S, 9R)-5-amino-6-(2, 3-difluorophenyl)-6, 7, 8, 9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl] 4-(2-oxo-3H-imidazo[4, 5-b]pyridin-1-yl)piperidine-1-carboxylate;sulfuric acid;trihydrate
CAS	1374024-48-2
Molecular Weight	1221.2
Molecular Formula	C56H64F4N12O13S
SMILES	C1C[C@H](C2=C(C=CC=N2)[C@H]([C@@H]1C3=C(C(=CC=C3)F)F)N)OC(=O)N4CCC(CC4)N5C6=C(NC5=O)N=CC=C6.C1C[C@H](C2=C(C=CC=N2)[C@H]([C@@H]1C3=C(C(=CC=C3)F)F)N)OC(=O)N4CCC(CC4)N5C6=C(NC5=O)N=CC=C6.O.O.O.OS(=O)(=O)O