Tropisetron HCl – (105826-92-4)

Tropisetron hydrochloride is a hydrochloride salt of tropisetron, a selective serotonin 5-HT3 receptor antagonist used primarily as an antiemetic to prevent nausea and vomiting induced by chemotherapy and radiotherapy. It competitively binds to and blocks the action of serotonin at 5-HT3 receptors located peripherally on vagus nerve terminals in the gastrointestinal tract and centrally in the chemoreceptor trigger zone of the area postrema in the central nervous system. This action results in the suppression of chemotherapy- and radiotherapy-induced nausea and vomiting.

In addition to its antiemetic properties, tropisetron hydrochloride exhibits neuroprotective effects, acting as a calmodulin inhibitor and an α7-nicotinic acetylcholine receptor (α7-nAChR) agonist. Tropisetron hydrochloride is also being investigated for its potential in reducing neuroinflammation and cognitive deficits in conditions such as Alzheimer’s disease and multiple sclerosis.

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Sources:

https://en.wikipedia.org/wiki/Tropisetron
https://pubchem.ncbi.nlm.nih.gov/compound/656664
https://www.medchemexpress.com/Tropisetron-Hydrochloride.html
https://www.medkoo.com/products/5160
https://www.cancer.gov/publications/dictionaries/cancer-drug/def/tropisetron-hydrochloride